It accumulates as unmetabolized folic acid (UMFA) and competes with active folates for receptors. Conversion between the two active forms is unreliable : it requires multiple enzymes (MTR, MTRR, SHMT, MTHFR, MTHFS) all working properly, and is easily blocked by low glutathione, B12 deficiency, heavy metals, or oxidative stress
However, very high doses from supplements or injections may lead to certain side effects in some individuals
If you need to dose away from your workspace, carry the vial in a cold pack and draw on-site instead of pre-loading a syringe
These applications are very narrow, but health influencers would have you believe that everyone can benefit from these supplements because everyone, of course, needs to detox
Lastly, B12 can be taken orally, through a variety of food sources including eggs, fish and fortified cereals